Global Leaders in Drug Discovery

For over two decades, Piramal Pharma Solutions has established itself as a leader in drug discovery services, partnering with a diverse range of clients, including large and mid-sized pharmaceutical companies, biotech firms, and academic institutions worldwide. Our end-to-end solutions are backed by the support of an integrated, cutting-edge facility with a dedicated team of over 300 professionals, offering 24/7 analytical support. The site features forward integration capabilities with our drug substance and formulation sites, ensuring consistent support and an uninterrupted flow when your program moves past the discovery phase.

With our expertise and commitment to scientific excellence, we are well-equipped to carry your discovery program to success with the utmost precision and efficiency.

Drug Discovery Services

Discovery Chemistry

  • Compound synthesis: final compounds building blocks, scaffolds, focused libraries, reference standards/impurities/metabolites
  • Advanced reactions: metal-mediated, organometallic, high-pressure, high-temperature reactions
  • Protective group strategies, liquid phase parallel synthesis, ozonolysis
  • Enantiomer separation, asymmetric synthesis, chiral resolution
  • Catalyst and reaction screenings
  • Discovery phase chemical development
  • Specialty chemistry: carbohydrates, nucleosides, PROTACs, payload-linkers, macrolides/macrocycles, natural products, isotopic, electrochemistry, photochemistry, fluorescent tagging
  • Database of 35,000 chemicals (16,000 unique building blocks)
Creams and ointments

Analytical Chemistry Support

  • Chiral purification (gram-scale by Super Critical Fluid Chromatography)
  • Prep HPLC purification services
  • Impurity isolation & characterization: NMR analysis,1H-NMR,13C-NMR, 2D experiments
  • Qualitative & quantitative analysis by HPLC
  • LCMS analysis with a single quadrupole mass detector
  • Bioanalytical services for small molecules (non-GLP): method development, method validation, bio-sample analysis
Commercial manufacturing and packaging of OSDs and LCOs

In Vitro Biology

  • Assay development
  • Target-based screening assays
  • Phenotype-based screening assays
  • Biochemical and cellular assays, multiplex assays, & primary/secondary functional assays
  • Hit identification, hit-to-lead, & lead optimization
  • Protein engineering
  • Selectivity studies
  • Evaluation across multiple formats: fluorescence, luminescence, alphascreen, MS, etc.
  • Assay validation using tool compounds
Commercial manufacturing and packaging of OSDs and LCOs

DMPK (In Vitro ADME & In Vivo PK*)

  • Absorption, distribution, metabolism, & excretion (ADME) solutions
  • Physiochemical screening
  • Permeability & solubility screening
  • Protein binding assays
  • Bioavailability studies
  • Rapid pilot PK studies for early reclinical support
  • Drug metabolism
  • Drug-drug interaction
  • P-Glycoprotein substrate & inhibition
  • Preliminary BCS permeability (non-GLP)
  • Metabolite identification (without structure elucidation)
  • IND/NDA/ANDA enabling safety evaluations
*In vivo testing services conducted through a third-party partner
Creams and ointments

Route Scouting

  • Phase-appropriate route identification
  • Custom solutions tailored for scalable routes
  • Rapid access to scaffold structures
  • Feasibility evaluations
  • Proof of concept sample generation
  • Focus on speed & initial delivery of gram quantities
  • Streamlined processes & reduced steps for intermediates
  • Reduced cost of intermediates during early screening
Creams and ointments

Pre-GMP Scale-Up Lab

  • Biology & early toxicology studies
  • Multigram to kg synthesis
  • 50 to 200L capacity
  • Temperature Range: -50°C to +150°C
  • Pressure vessel 10L (up to 75 bar) for hydrogenation & other pressure-dependent chemistries
  • Large-scale column chromatography (up to 2kg loading)
  • Rapid building block synthesis
  • Quick generation of material using a fit-for-purpose synthesis
  • Cryogenic reactions down to -35°C at different scales
  • Hydrogenation reactions
  • HPLCs for in-process monitoring
Creams and ointments

Powering Our Drug Discovery Services

Piramal Pharma Solutions’ Drug Product Facility in Sellersville, USA

Piramal Discovery Solutions
Ahmedabad, India

Discovery Chemistry, In Vitro Biology, DMPK, Route Scouting, Pre-GMP Scale-Up Services

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Let’s Get Started

Contact us today to learn more about how we can enhance your discovery programs and streamline the development of your products!

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Piramal Pharma Solutions